If you have a big electric pump don't forget to drop a line size for every fitting in the line, so the least amount of fitings and bends as possible.
if the motor needs twin -06 at the carb this means starting with -10 out of the tank or fuel cell into the filter, -08 out of the pump/filter ( close coupled) up to the reg, then twin -06 out of the reg to the carb
if the motor needs -08 at the carb you start with -12 at the tank
If you have a Holley blue then forget this as the inlet/outlet is tiny anyway, this becomes the restriction.
Take the line that goes to the reg right up to the rad support then back towards the carb, hang the reg on the lines as close to the carb as possible.
Taking the line to the rad support means there is a short peice of line that gravity can act on in your favour pushing fuel to the reg on launch ( the rest of the line under the car gravity works on the fuel in that against you, may as well get a little bit of an advantage back)
Mounting the reg as close to the carb as possible means it will respond much faster
http://www.barrygrant.com/bgfuel/default.aspx?page=85